Please enable JavaScript.
Coggle requires JavaScript to display documents.
Felodipine Screenshot_20200419-212432 (Mechanism of action (Decreases…
Felodipine
Brand names
Plendil
Indications
Treat high blood pressure
Prevent stroke, heart attacks and kidney problems
Route of administration
Oral
Contraindications
Shock
Severe hypotension
Pregnant and breastfeeding women
Dihydropyridine hypersensitivity
Storage
Protect from light
Store at a controlled temperature
Between 20-25°C
Mechanism of action
Decreases arterial smooth muscle contractility
And subsequent vasoconstriction
It reversebly competes against nitredipine and DHP
Calcium ions entering the cell binds to calmodulin
Calmodulin binds to activate myosin light chain kinase
Catalyzing phosphorylation of regulatory light-chain subunits
Of myosin
Amplication is achieved by calcium-induced release
From sarcoplasmic reticulum through ryanodine receptors
Decreasing contractive activity
Of smooth muscle cells
Resulting in vasodilation
And overall decrease in blood pressure
Side effects
Dizziness
Lightheadedness
Headache
Flushing
Stomach upset
Pounding heartbeat
