Anistreplase
Contraindications
Storage
Dosage
Indications
Side Effects
Mechanism of action
Route of Administration
Myocardial infarction
Pulmonary embolism
Thromboembolic disorders
Haemorrhage and recent stroke
Cerebral neoplasm
Severe hypertension
Pregnancy
Increased risk of cerebral bleeding
IV 30 u over 5 mins as a single dose img immediately after onset of symptoms
Anistreplase consist of a complex of the lys-form of plasiminogen and streptokinase with the addition of a p-anisoyl
Group that undergoes deacylation upon IV injection to release the active complex which converts plasminogen to plasmin which has fibrinolytic activity
Bleeding
Irregular heart rhythms
Intravenous (IV)
store at room temperature of 20°c to 25°c