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Hydrochlorothiazide Screenshot_20200419-101004 (Mechanism of action…
Hydrochlorothiazide
Brand names
Esidrix
Hydrodiuril
Microzide
Oretic
Indications
Treat high blood pressure
Diabetic insipidus
Swelling caused by heart failure
And liver damage
Side effects
Low blood pressure
Dizziness
Headache
Erectile dysfunction
Tingling in your hands, legs and feet
Unusual weakness
Renal tubular acidosis
Kidney stones
Mechanism of action
Belongs to thiazide class of diuretics
Reduces blood volume by acting on the kidneys
To reduce sodium reabsorbtion
In the distal convulated tubules
The site of action in the nephron
Appears electoneutral NaCl co-transporter
By impairing Na ions in the distal convulated tubular
It induces a natriuresis and concomitant water loss
Thiazides increase reabsorbtion of Cl
HCL lowers peripheral vascular resistance
Route of administration
Oral
Storage
Keep in original container
Keep out of reach of children
Store at room temperature
Do not allow liquid to freeze
Contraindications
Unknown thiazide hypersensitivity
People with hepatic disease
