Hydrochlorothiazide Screenshot_20200419-101004

Brand names

Esidrix

Hydrodiuril

Microzide

Oretic

Indications

Treat high blood pressure

Diabetic insipidus

Swelling caused by heart failure

And liver damage

Side effects

Low blood pressure

Dizziness

Headache

Erectile dysfunction

Tingling in your hands, legs and feet

Unusual weakness

Mechanism of action

Renal tubular acidosis

Kidney stones

Belongs to thiazide class of diuretics

Reduces blood volume by acting on the kidneys

To reduce sodium reabsorbtion

In the distal convulated tubules

The site of action in the nephron

Appears electoneutral NaCl co-transporter

By impairing Na ions in the distal convulated tubular

It induces a natriuresis and concomitant water loss

Thiazides increase reabsorbtion of Cl

HCL lowers peripheral vascular resistance

Route of administration

Oral

Storage

Keep in original container

Keep out of reach of children

Store at room temperature

Do not allow liquid to freeze

Contraindications

Unknown thiazide hypersensitivity

People with hepatic disease