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Estrogen (Female hormonal drugs) (Premarin (Side effects (Stomach upset,…
Estrogen (Female hormonal drugs)
Premarin
Contra-indications
Undiagnosed abnormal genital bleeding
Suspected, or history of breast cancer
Active DVT,
Liver impairrment or disease
Suspected pregnancy
Side effects
Stomach upset
Nausea and vomiting
Bloating
Breast tenderness
Headache or weight changes
Unusual vagina bleeding
Indications
Menopausal Vasomotor Symptoms
Female Hypogonadism
Abnormal Uterine Bleeding.
Breast Cancer Palliation.
Primary Ovarian Failure
Storage conditions
Store at 20° to 25°C
Dispense in a well-closed container
Mechanism of action
An Estrogen that increases combination of DNA, RNA, and various proteins in target tissues
Reduces release of gonadotropin-releasing hormone from the hypothalamus.
Reduces follicle-stimulating hormone (FSH) and luteinizing hormone (LH) release from the pituitary gland.
Route of administration
Oral
Intramuscular
Intravenous
Cream
Estradiol
Contra-indications
Undiagnosed abnormal genital bleeding.
Known, suspected or history of cancer
Active deep vein thrombosis
Side effects
breast pain;
Darkening of the skin
Insomnia
Mood changes
cold symptoms
Headache
Back pain
Indications
Treatment of menopause symptoms such as hot flashes and vaginal changes
Prevent osteoporosis (bone loss) in menopausal women
treat low estrogen levels in women with ovarian failure
Storage conditions
tore at controlled room temperature 15° to 25 °C
Mechanism of action
Estradiol is a nuclear hormone
Acting on receptors present inside the cell,
To activate or deactivate transcription in the nucleus
Estradiol interacts with a target cell receptor (Erα or Erβ) within the cytoplasm of the cell.
Routes of administration
oral
Intramuscular
Subcutanous
Etonogestrel
Contra-indications
Allergy
Ideopathic vagina
Breast cancer
Eostrogen dependent cancer
Pregnancy
Side effects
Nausea
Cholestaic Jaundice
Vomiting
Acute pancreatitis
Indications
Post partum breast engorgement
Hormonal replacement
Palliation in Menopause
Osteoporosis
Storage conditions
Avoid in direct sunlight or at temperatures above 30°C
Mechanism of action
Inhibit the release of follicle stimulating hormone
Responsible for the growth of the endomentrial lining
Route of administration
Oral
Intramuscular