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Tacrolimus Screenshot_20200418-132459 (Side effects (Shaking, Headache,…
Tacrolimus
Trade names
FK506
Route of administration
Oral
Sublingual
Topical
Intravenous
Indications
Treat graft-versus host disease
Crohn syndrome
Myasthenia grivis
Rheumatoid arthritis
Liver transplant rejection prophylaxis
Contraindications
Pregnant women
Cancer malignancy
Bad infection
Diabetes
Low magnesium in the blood
Low calcium
High blood pressure
Servere liver disease
Delirium
Lymphoma
Storage
Store at a room temperature
Keep in tightly closed container
Side effects
Shaking
Headache
Vomiting
Diarrhoea
Upset stomach
Loss of appetite
Trouble sleeping
Tingling hands
Mental problems
Seizures
Hypertension
Mechanism of action
Tacrolimus binds to intracellular protein FKBP12
Phosphatase activity of calcineurin is inhibited
Preventing desphorylation and translocation of various factored
Like nuclear factor of activated Tcells
And nuclear factor Kappa-Light-chain
Enhancer of activated Bcells
Therefore inhibits production of several cytokines
Also inhibiting 1L2 receptor expression
Inducing apoptosis and production of transforming
Beta cells
Leading to immunosuppressive activity
