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Sirolimus (Side effects (Thrombocytopenia, Hypertension, Anaemia, Nausea…
Sirolimus
Side effects
Thrombocytopenia
Hypertension
Anaemia
Nausea and vomiting
Abdominal pain
Increased creatinine
Peripheral oedema
Indications
Treatment of lymphangioleiomyomatosis(a rare lung disease)
Used to coat coronary stents
Organ rejection prevention
Mechanism of action
This happens via action on mTOR and blocks activation of T and B cells
It binds to cytosolk protein FK-binding protein 12(FKB12(
It inhibits 1L-2 and other cytokine receptor-dependent signal transduction mechanisms
Storage
Tabs are stored at room temperature
Oral solution is stored at 2-8°C
Contraindications
Hypersensitivity to sirolimus or its derivatives
Route of administration
Administered orally