obesity drugs
ORLISTAT
mechanism of action
works by inhibiting gastric and pancreatic lipases
the enzymes that breaks down triglycerides in the intestines.
when lipase activity is blocked,triglycerides from the diet are not hydrolised into absorbable free fatty acids and instead excreated unchanged.
indications
it is indicated for obesity management including weight loss and weight maintanance when used in conjunction with a reduced calorie diet.
contraindications
hypersensitivity to orlistat
reduced gallbladder function
pregnancy and breastfeeding
anorexia and bulimia
side effects
flatulance
fatty or oily stools
oily spotting on underwear
increased number of bowel movements
abdominal pain or discomfort
storage conditions
store in the temperature of 2-8 degrees celcious
route of administration
taken oraly
SIBUTRAMINE
route of administration
taken orally
storage conditions
capsules are stored at 25 degrees celcious
mechanism of action
it exerts its pharmalogical actions predominantly via its secondary M1 and primary M2 amine metabolities.
by inhibiting the reuptake of these neurotransmitters,
it promotes a sense of satiety and decrease in appetite thereby reducing food intake.
indications
for the treatment of obesity and maintanance of weight loss.
contraindications
contraindicated in patient with pscychiatric conditions as bulimia nervosa and serious depression
patients with history of a predisposition of drug or alcohol abuse
hypersensitivity to the drug or any of the inactive ingredience.
side effects
flu symptoms
sore throat
cough
runny or stuffy nose
high blood pressure
fast or pounding heart beat
seizures
it is contraindicated in malabsprption