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Zelodronic images (3) (Mechanism of action (Nitrogen containing bisphonate…
Zelodronic
Brand names
Zometa
Reclast
Storage conditions
Store at a refrigerator at 2 to 8 degrees for no longer
Than 24 hours if not opened
Indications
With multiple myeloma
Reduces amount of calcium released from bones into blood
Used in chemotherapy to treat bone problems occuring
Used to treat high blood calcium levels (hypercalcemia)
Contraindicationsf
Do not administer to a person with hypocalcemia
Not to be taken when pregnant
Not to be used when a person has poor renal function
Route of administration
Intravenous
Side effects
Tiredness
Muscle ache
Headache
Joint ache
Dizziness
Chills
Mechanism of action
Nitrogen containing bisphonate such as zoledronate acts as
Thereby inhibiting FFP synthase, the inhibition of this
Targets farnesyl pyrophosphate (FFP) synthase
Agonists of isophenoid diphosphate lipids
Enzyme in osteoclasts prevents biosynthesis of FFP and GGPP
Hydroxyapatite which is part of mineral matrix of bone also
This activity inhibits osteoclast activity thus reducing bone turnover
Action of zelodronic is based on bone tissue affinity for
