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METHYSERGIDE IMG_20200419_122654 (Contraindications (Severe hypertension,…
METHYSERGIDE
Mechanism of action
Methysergide is serotonin antagonist
It acts on central nervous system
A substance which may be involved in the mechanism of vascular headaches
Which directly stimulate the smooth muscle leading to vasoconstriction
To inhibit or block the effect of serotonin
Indications
Used to treat episodic and chronic cluster headaches
Used to prevent migraine
Contraindications
Severe hypertension
Coronary artery disease
Severe arteriosclerosis
Phlebitis
Peripheral vascular disease
Cellulitis of the lower limbs
Pulmonary disease
Lactation
Pregnancy
Collagen disease
Hypersensitivity tothe drug or to the tartrazine
Side effects
Vomiting
Heartburn
Nausea
Abdominal pain
Weakness or poor coordination
Insomnia
Drowsiness or dizziness
Diarrhea or constipation
Weight gain
Rash or facial flushing
Muscle or joint aches or discomfort
Storage condition
Store in room temperature away from light and moisture
Keep it away from children and pets
Route of administration
Oral
