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ERGOTAMINE IMG_20200419_122713 (Mechanism of action (Leads to…
ERGOTAMINE
Mechanism of action
Leads to vasoconstriction
Which correlate with the relief of migraine headache
Including those on arteries - venous anastomoses
2-activation of 5-HT receptor on sensory nerve ending of the trigeminal system
One- activation of 5-HT receptor located on intracranial blood vessels
Results in the inhibition of pro-inflammatory neuropeptide release
Acts on migraine by one of two proposed mechanism
Indications
To abort or prevent vascular headaches
Contraindications
Severe arteriosclerosis
Thrombophlebitis
Peripheral vascular disease
Coronary artery disease
Side effects
Fastor slow heart rste
Muscle pain in your arms or legs
Sudden headache
Leg weakness
Sudden numbness or weakness
Numbness or tingling and a pale blue-colored appearance in your fingers or noes
Storage
Room temperature away from moisture hest and light
Route of administration
Inhalation
Intravenous
Rectal
Oral
