Please enable JavaScript.
Coggle requires JavaScript to display documents.
Renal Physiology (Solute Reabsorption (The proximal tubule reabsorbs the…
Renal Physiology
Solute Reabsorption
-
-
-
-
-
-
-
-
The distal tubule and collecting duct respond to systemic signals to alter salt excretion as required
The distal tubule and collecting duct control the ultimate rate of excretion of electrolytes and water to maintain homeostasis despite variations in dietary intake and extrarenal losses of salts and water
Calcium is reabsorbed in the distal nephron & connecting segment, regulated by:
Parathytoid hormone
To increased apical uptake of Ca2+ in these segments by increasing the activity of the apical Ca2+ channel
-
Calcitonin
Reduces the serum Ca2+ concentration, largely by stimulating Ca2+ deposition in bone
Glomerular Filtration
-
-
:rabbit: The structure of the glomerulus allows efficient, selective filtration
-
Wall of capillary
-
-
Visceral epithelium
:star: A layer of intricate, interlocking cells called podocytes
Glomerular tuft
:check: Encased within Bowman's capsule, which is lined with a single layer of epithelium
-
:lion_face: Glomerular filtration rate is measured by determining the plasma clearance rate of a substance
Determination of GFR relies on the concept of clearance, that is, the rate the plasma is cleared of a substance
Rate of clearance is measured by the rate of elimination of a substance divided by its plasma concentration
Cx = (UxV)/Px
:check: Cx: Volume of plasma cleared of substance X per unit time
:check: Ux: Urine concentration of substance X
:check: V: Volume of urine collected divided by the time period of the collection
:check: Px: Plasma concentration of substance X
-
-
Water Balance
-
-
-
-
-
Solute reabsorption by the medullary thick ascending limb and collecting duct generates and maintains medullary hypertonicity