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Probenecid (Contraindications (Acid-base imbalance,nephrolithiasis,Tumor…
Probenecid
Contraindications
Acid-base imbalance,nephrolithiasis,Tumor lysis syndrome
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Renal fauilure,Renal impairment
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Infants,neonates,children less than 2 years
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Mechanism of action
Probenecid may also reduce plasma binding of urate & inhibits renal secretions of uric acid at subtherapeutic concentration
Inhibits the tubular reabsorption of urate,thus increasing urinary excretion of uric acid & decreasing serum urate levels
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