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Penicillamine Screenshot_20200412-102159-1 (Nursing implications (Stopped.…
Penicillamine
Name of a drug and class
Name: Penicillame
Class: Antirheumatic drugs.
Mechanism of action
Metal ion chelation.
Dissociation of macroglobulins.
Acts by several mechanism including-
It inhibits release of lysosomal enzymes-
From the cells in inflamed connective tissue.
Indication
It is chelating agent.
Treatment of rheumatoid arthritis
Nursing implications
Stopped.
It must be used with caution in patients with-
If the treatment is not effective in 6 months therapy must -
Renal impairment or hepatic impairment.
Monitor intake and output to check functioning of kidneys.
Monitor patients in adverse reactions.
Contraindications
Contraindicated with gold salts therapy.
Contraindicated with anti-malarial drugs.
Adverse effects
Nausea
Cytopenia.
Proteinuria
Damage to kidneys.
Skin rashes
Dose and route
250mg daily for a month
Route: orally.
Storage
Store in a temperature of 15'C to 30'C
Store away from heat and direct sunlight.
