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Fenofibrate image (Indications (Mixed dyslipidemia, Primary…
Fenofibrate
Indications
Mixed dyslipidemia
Primary hypercholesterolemia
Severe hypertriglyceridemia
Statin are contraindicated
Statins are not tolerated
Contraindications
Gallbladder disease
Hypersensitivity to fenofibrate
Liver disease
During pregnancy
Renal impairment
Route of Administration
Oral route
Storage conditions
Store in dry place
Store away from direct light
Store in the original package
store in a locked cupboard
Do not store above 25°C
Mechanism of Action
Activation of PPARα activates transcription of gene transcription
Translation that generates peroxisomes filled with hydrogen peroxide
Increases lipolysis, activating lipoprotein lipase, and reducing apoprotein C-III
Hydroxyl radicals that also participate in lipolysis
Activates peroxisome proliferator activated receptor alpha
Side effects
Abdominal pain
Yellowing eyes
Loss of appetite
Dark urine
Nausea and vomiting
