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Nicorandil Nocadri (Storage conditions (Protect from moisture, Store in a…
Nicorandil
Storage conditions
Protect from moisture
Store in a locked cupboard
Store in the original package
Check expiry date
Do not store above 25°C
Contraindications
Cardiogenic shock
Low blood volume
Hypotension
Pulmonary oedema
Hypersensitive to nicorandil
Indications
Angina pectoris
other heart conditions
Route of Administration
Oral route (PO)
Intramuscular route (IMI)
Intravenous route (IV)
Side effects
Headache
Ulcers in your GI tract
Feeling dizzy
Being sick (vomiting)
Itchy, swollen or watery eyes
Mechanism of Action
Activates sulfonylurea receptor 2 channels to cause hyperpolarization
Hyperpolarization leads to vasodilation
Binds to sulfonylurea receptor 2 in ATP-sensitive potassium channel
Direct relaxation of venous vascular system arises
Activates and opens ATP-sensitive potassium channels
