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Alzheimer Disease (Symptoms (Short-term memory loss, Disortientation,…
Alzheimer Disease
Symptoms
Short-term memory loss
Disortientation
Apraxias
Changes in personality and affect
Depression
Impaired language
Agitation/hostility
Sleep problems
Chronic debilitation
Pathophysiology
Accumulation of amyloid beta triggering a cascade if morphologic changes
Atrophy of cerebral cortex and enlargment f ventricles
Neuritic plaques and neurofibrillary tangles
Decrease in choline acetyltransferase activity
Treatments
No cure
Slow progression
Cholinesterase inhibitors
Antiinflammatory agents and antioxidants
Mood stabilizers and antipsychotics
Self-help groups for family and friends
Daycare and respite centers
Labs/Diagnostics
Mini-mental state examination
Brain imaging
Metabolic screening
Risks
Genetics