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Nitroglycerin nitroglycerin-sublingual-table (Mechanism of Action (Cyclic…
Nitroglycerin
Indications
Anal fissures
Peri-operative hypertension
Coronary artery spams
Acute heart failure
Chest pain (angina)
Contraindications
Low blood pressure
Anemia
GI hypermotility
Hypersensitivity to Nitroglycerin
Dehydration
Side effects
Dizziness
Nausea
Headache
Rash
Lightheadedness,
Route of Administration
Intravenous route
Sublingual
Transdermal
Storage conditions
Keep this drug away from light
Keep drug in glass bottle it comes in
Keep it between 15°C and 30°C
Keep in a dry place
Store at room temperature
Mechanism of Action
Cyclic guanosine monophosphate is synthesised
Activation of protein kinase-dependent phosphorylation
Guanylate cyclase enzyme is activated
Dephosphorylation of myosin light chain of smooth muscles
Becomes converted to nitric oxide
Relaxation and increased blood flow in veins & arteries
