Aciclovir

Mechanism of action

Acyclovir is converted to it triphosphate form, acyclovir triphosphate (ACV-TP), which competitively inhibits viral DNA polymerase, incorporated into and terminate the growing viral DNA chain and inactivate the viral DNA polymerase.

Indications

Treat cold sores on the lips and face.

Acyclovir topical ointment is used to treat genital herpes lesion.

It slows the growth and spread of the herpes virus so that the body can fight off infections.

Contraindications

Hypersensitivity

Renal failure/ impairment

Immunocompromised host

Potential risk of thrombotic thrombocytopenic purpura (TTP)

Hemolytic Uremic Syndrome (HUS)

Side effects

Mild, temporary burning, stinging or itching when medication is applied.

Dry, cracked, or peeling lips

Dryness or flanking of treated skin

Storage conditions

Keep acyclovir in the container that it came in and keep the container slightly closed.

Do not use acyclovir if the original seal over the container is broken or missing.

Store acyclovir injection for intravenous infusion at room temperature 68°F to 77°F (20°C o 25°C).

Throw away acyclovir that is no longer needed or expired.

Store acyclovir capsules, tablet and suspension at 59°F (15° C to 25°C). Protect acyclovir capsules and tablets from moisture.

Keep acyclovir and all medications out of reach of children.

Route of administration

Intravenous

Oral

Topical ( including the ointment)