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Probenecid probenecid_ (Mechanism of Action (Decreases serum urate levels,…
Probenecid
Indications
Elevated Serum Uric Acid
Bacterial Infections
Hyperuricemia
Gout
Gouty arthritis
Mechanism of Action
Decreases serum urate levels
Reduces plasma binding of urate
Increases urinary excretion of uric acid
Inhibits renal tubular transporter
Inhibits renal secretion of uric acid
At subtherapeutic concentrations
Side effects
Dizziness
Headache
Frequent urination
Loss of appetite
Sore gums
Storage conditions
Store in a cool dry place
Keep all medicines in a looked cupboard
Store between 15-30 degrees C
Protect from light
Route of Administration
Oral route (PO)
Contraindications
Aplastic anemia
kidney stone (uric acid)
Bone marrow depression
Peptic ulcer disease.
Hypersensitivity probenecid
