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Colchicine colchicine-e1438717583334 (Mechanism of Action (Inhibits T…
Colchicine
Side effects
Pain in the abdomen
Constipation
Drowsiness
Diarrhea
Joint pain
Route of Administration
Oral (PO)
Indications
Behçet's disease
Pericarditis
Gout
Familial Mediterranean fever
Chondritis
Storage conditions
Keep away from light
Store in cool dry place
Store at room temperature 20°C-25°C
Mechanism of Action
Inhibits T-lymphocytes activation and adhesion to endothelial cells
Impairs cell secretion of procollagen
Reduces mobility of polymorphonuclear cells
Promotes a larger collagenyolytic action
Causes cessation of mitosis in metaphase
Inhibits cell mediated immune reponses
Contraindications
Breastfeeding
Pregnant women
KIdney failure
Liver disease
Grapefruit or grapefruit juice
