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NUCLEOSIDE REVERSE TRANSCRIPTION INHIBITORS (SIDE EFFECTS (Pancreatitis,…
NUCLEOSIDE REVERSE
TRANSCRIPTION INHIBITORS
MECHANISM OF ACTION
These nucleosides lack a substance needed to extend tbe DNA Chain
Chain cannot lengthen and insert itself into the host DNA
Competing with the naturally occurring nucleosides within the cell.
INDICATIONS
Chronic Hepatitis
Prevention of maternal transmission of HIV
Treatment of HIV
STORAGE CONDITIONS
Store in a cool dark place
SIDE EFFECTS
Pancreatitis
Hepatomegaly
Serious to fatal hypersensitivity reactions
Changes in body fat distribution
CONTRAINDICATIONS
Several renal impairment
Bone marrow suppression
Hepatic Dysfunction
ROUTE OF
ADMINISTRATION
Intravenous
Oral