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CYTOTOXIC ANTIBIOTICS (SIDE EFFECTS (Bone marrow suppression, Nausea,…
CYTOTOXIC ANTIBIOTICS
ROUTE OF ADMINISTRATION
Intravenous
SIDE EFFECTS
Bone marrow suppression
Nausea
Renal toxicity
Vomiting
Alopecia
Malaise
Anorexia
MECHANISM OF
ACTION
Interferes with cellular DNA Synthesis
By inserting themselves between base pairs in the DNA Chain
Either breaking up DNA links or preventing DNA Synthesis
This causes a mutant DNA Molecule leading to cell death
INDICATIONS
Breast cancer
Ovarian cancer
Lung cancer
Metastatic colorectal cancer
CONTRAINDICATIONS
Pregnancy And lactation
Cardiac problems
Known allergy to drug
Pulmonary problems
Storage conditions
Protect from light. Room temperature 15-25°C