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ANTIMETABOLITES (MECHANISMS OF ACTION (And RNA in rapidly dividing cells…
ANTIMETABOLITES
MECHANISMS OF
ACTION
And RNA in rapidly dividing cells
Purine analogues lead to the synthesis of hypoxanthine and guanine analogues
This leads to suppression of the synthesis of DNA
Pyrimidine analogues inhibits the biosynthesis or pyrimidine nucleotides such as DNA
Folic acid analogue ihibits the enzyme dihydroplate reductase
SIDE EFFECTS
Renal toxicity
Nausea
Interstitial pneomonitis
Mucous membrane deterioration
Pulmonary toxicity
CONTRAINDICATIONS
Renal and hepatic dysfunction
GI Ulceration
Known allergy to drug
Bone marrow suppression
Pregnancy and lactation
INDICATIONS
Metastatic breast cancer
GIT Cancers
Choriocarcinoma
Metastatic colorectal cancer
Acute lymphoblastic leukemia
ROUTE
Intravenous
Storage conditions
Dry cool place at room temperature 15-25°C