Please enable JavaScript.
Coggle requires JavaScript to display documents.
Folate Deficiency (Common Findings (Stomatitis and painful ulcerations in…
Folate Deficiency
Common Findings
Cachetic or malnourished appearance (McCance & Rote, 2019, p 934)
Severe cheilosis (scales/fissures formation of the lips and corners of the mouth) ((McCance & Rote, 2019, p 934)
Stomatitis and painful ulcerations in the mouth and tongue (McCance & Rote, 2019, p 934)
Cause dry mouth, infections, nutritional deficiencies, autoimmune diseases (McCance & Rote, 2019, p 934)
Gastrointestinal: dysphagia, flatulence, loose diarrhea, malabsorption disorders - Chron;s disease and ulcerative colitis (McCance & Rote, 2019, p 934)
Neurologic: Pernicious anemia; usually related to thiamine deficiency - correlates with folate deficiency (McCance & Rote, 2019, p 934)
Anemia levels (McCance & Rote, 2019, p 934)
Treatments
Oral folate with appropriate correlation with serum blood levels (McCance & Rote, 2019, p 934)
Daily dose of 1 mg for most individuals (McCance & Rote, 2019, p 934)
-
Pregnancy: recommended dose of 0.1 o 0.4 mg/day (McCance & Rote, 2019, p 934)
Etiology
Folate is needed for RNA and DNA synthesis for maturing erythrocytes (McCance & Rote, 2019, p 933)
Folates help with the synthesis of thymine and purines; which converts homcysteine to methionine (McCance & Rote, 2019, p 933)
Inadequate daily folate intake (McCance & Rote, 2019, p 933)
Causative/Risk Factors
Usually caused by a similar pathway of B12 deficiency (McCance & Rote, 2019, p 933)
Dietary intake of 50 to 200 mcg/day is needed for adequate levels (McCance & Rote, 2019, p 934)
Pregnant and lactating mothers will need an increased folate intake to prevent any neonatal birth defects (McCance & Rote, 2019, p 934)
Adequate folate levels during pregnancy will help reduce homocysteine levels (McCance & Rote, 2019, p 934)
Can help reduce the risks of developing coronary artery disease risks (McCance & Rote, 2019, p 934)
Neural tube defects - birth defect can be avoided if maternal intake of folic acid is supplemented before and early in pregnancy ((Adebo, Dairo, Ndikom, & Adejumo, 2017).)
400 mg of synthetic folic acid supplementation was suggested by the World Health Organization (Adebo, Dairo, Ndikom, & Adejumo, 2017).
Neonates who are born with neural tube defects have a 15-fold increased risk of death during the first year of life (Adebo, Dairo, Ndikom, & Adejumo, 2017).
9-10% of children die during this period (Adebo, Dairo, Ndikom, & Adejumo, 2017).
Diagnostic Tests
Serum Levels (McCance & Rote, 2019, p 934)
Signs and Symptoms (McCance & Rote, 2019, p 934)
Pathophysiologic
Formation of megablastic cells (clumped nuclear chromain) from impaired DNA synthesis of folate deficiency (McCance & Rote, 2019, p 934)
May cause anemia if chronic condition persists (McCance & Rote, 2019, p 934)