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NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR (ETRAVIRINE (Side effects…
NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR
ETRAVIRINE
Side effects
Tingling and numbness of feet
Diarrhoea, fatigue
Change in body fat
Rash
Peripheral neuropathy
Contraindications
Hepatic disease
Breastfeeding
Hypersensitivity to the drug
Route of administration
Oral
Indication
HIV type 1 infection
Storage condition
Stored at room temperature (20-25 degrees C)
Mechanism of action
Directly dinds reverse transcriptase and blocks DNA dependent and RNA dependent polymerase acivity.
Does not inhibit human DNA polymarase
Inhibits reverse transcriptase enzyme of HIV-1
Nevirapine
Side effects
Severe anaphylaxis
Epidermal necrolysis
Drug rash
Eosinophilia
Hepatotoxicity
Contraindications
Post exposure prophylaxis
Baseline CD4 count below 250 (in women), below 400 in men
Hepatic impairment
Route of administration
Orally
Storage condition
Store at room temperature (20-25 degrees C)
Indication
HIV-1 infection
Mechanism of action
Binds to the reverse transcritase
Blocks the RNA-dependent and DNA-dependent polymerase activities
Causes disruption of enzyme catalytic site
Does not compete with nucleoside triphosphates.