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NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS (ABACAVIR (Mechanism of action…
NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
ABACAVIR
Contraindications
Liver problems
Severe liver disease
Breastfeeding
Pancreatitis
Side effects
Nausea, headache
Dreams/ sleep disorder
Malaise and fatigue
Indication
HIV and AIDS
Route of administration
Orally
Mechanism of action
Inhibits viral replication
Intracellularly converted by cellular enzymes to active metabolite
Inhibits activity of HIV-1 reverse transcriptase
Incorporates into viral DNA
Viral DNA growth is terminated
Storage condition
Stored in room temperature
TENOFOVIR
Mechanism of action
Disphosphation inhibits HIV-1 reverse transcriptase and hepatitis B polymerase.
Directly binds with the deoxyribonucleotide subtrate
Manages HIV viral load through decreased viral replication
Integrates into DNA causing viral DNA termination
Antiretroviral which blocks reverse transcriptase
Indications
HIV infection
Hepatitis B therapy
Contraindications
Lactic acidosis
Severe hepatomegaly
Side effects
Nausea, vomititng
Headache
Flatulence
Abdominal pain
Anorexia
Route of administration
Orally
Storage conditions
Store in room air