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ANTIVIRAL AGENTS (ACICLOVIR (Indications (Herpes simplex virus infections,…
ANTIVIRAL AGENTS
ACICLOVIR
Mechanism of action
Inhibits activity against human herpes viruses
Lowers the ability of the herpes virus to multiply
Highly selective synthetic purine nucleoside analogue
Indications
Herpes simplex virus infections
Recurrent genital herpes
Prophylaxis of herpes in immunocompromised patients
Shingles
Chickenpox
Side effects
Nausea
Vomiting
Diarrhoea
Headache
Contraindications
Hypersensitivity to aciclovir
Kidney disease
Dehydration
Route of administration
Oral with a full glass of water
Storage conditions
Stored in room temperature of 15-20 degrees C
AMANTADINE
Mechanism of action
Increases synthesis and release of dopamine
Also an antiparkinson agent
Used in prophylactic treatment of influenza A
Interferes with a viral protein needed for the viral particle to un-coat once inside the cell
Indications
Chemoprophylaxis
Prophylaxis
Signs and symptoms of influenza A virus
Parkinsonism
Containdications
Amantadine hypersensitivity
Renal failure
Heart failure
Seizure disorder
Depression
Side effects
Blurred vision
Nausea, loss of appetite
Headache
Dizziness
Storage condition
Stored in room temperature
Route of administration
Orally