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estrogen therapy for osteoporosis (side effects (vaginal bleeding, gall…
estrogen therapy for osteoporosis
name of drugs
Lasofoxifene
Raloxifene
side effects
vaginal bleeding
gall bladder disease
weight gain
breast tenderness
fluid retention
contraindications
Estrogen-dependent cancers for example, breast cancer
Pregnancy
Allergy to estrogen
History of blood clots or clotting disorder
indications
Treatment of postmenopausal women with osteoporosis at high risk for fracture
recreate the bone-preserving effects of estrogen.
. Estrogen may help decrease bone loss after menopause
storage conditions
Do not store above 25°C. Store in the original package
mechanism of action
Estrogen effects may be mediated in part by growth factors and interleukins
The major physiological effect of estrogen is to inhibit bone resorption. Bone cells have two kinds of intracellular steroid receptors for estrogen.
route of administration
transdermal
oral