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SELECTIVE B2 AGONISTS (DOBUTAMINE (Mechanism of action (Synthetic…
SELECTIVE B2 AGONISTS
DOBUTAMINE
Side effects
Angina pain
Shortness of breath
Nausea
Increased heart rate and blood pressure
Storage conditions
Stored at room temperature between 20-25 degrees C
Contraindications
Idiopathic hypertrophic subaortic stenosis
Tachycardia
Hypertensitivity to the drug
Hypovolemia
Acute coronary disease
Route of administration
Intravenous (IV) injection
Indications
Inotropic support for cardiac failure
Hypertensive
Vasodilation
Considerations
May cause increased heart rate or blood pressure
Allergic reactions, asthmatic episodes
Continuously monitor ECG
Mechanism of action
Synthetic catecholamine
Acts on alpha-1 and beta-1 adrenergic receptors
Stimulates these receptors and produce inotropic effects in the heart
also produces chronotropic effects
Alpha-1 activity balances the beta-2 agonist effect
Increases myocardiac contractility
Elevates afterload pressure in acute cardiac failure
DEXMEDETOMINE
Mechanism of action
Specific alpha-2 adrenoceptor agonist
Binds to presynaptic alpha-2 adrenoceptors
Inhibits the release of norepinephrine
Terminates propagation of pain signals
Decreases blood pressure and heart rate
Indications
Sedation
Intubation or mechanical ventilation
During ICU treatment
Pain relief, analgesia
Anxiety reduction
Contraindications
AV blockage
Hepatic disease
Dialysis, renal disease
Hypovolemia
Side effects
Hypotension
Bradycardia
Sinus arrest
Transient hypertension
Dry mouth
Storage conditions
Stored at controlled room temperature between 15-30 degrees C
Route of administration
Intravenous (IV) injection