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Hyperadrenocorticism in dogs (Clinical Sign (polydipsia, polyuria,…
Hyperadrenocorticism in dogs
Types
Exogenous (caused by factors outside the body)
Endogenous (caused by factors within the body)
Clinical Sign
polydipsia
polyuria
polyphagia
heat intolerance
lethargy
muscle weakness
recurrent urinary tract infections
Diagnosis
Screening Test
Urine Cortisol: Creatinine Ratio
Low-Dose Dexamethasone Suppression Test
ACTH Stimulation Test
Confirmatory Test
High-Dose Dexamethasone Suppression Test
Endogenous ACTH Concentration
Diagnostic Imaging
Treatment
Medical
Mitotane
Derivative of the insecticide dichlorodiphenyldichloroethane, causes cell necrosis in two of the three layers of the adrenal glands — the zona fasciculata and zona reticularis.
Ketoconazole
Agent that decreases cortisol production by inhibiting the enzymes necessary for glucocorticoid synthesis.
Trilostane
A synthetic, hormonally inactive steroid that inhibits the production of cortisol, aldosterone, and sex hormones.
Surgical
Adrenalectomy
Radiation
Associated with a high rate of response; however, most dogs and cats require ancillary trilostane or mitotane therapy for several months after radiation treatment because of residual ACTH secretion.