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Porcine: Multi-Systemic Disease (CSF (CS (PM (die rapidly- few signs,…
Porcine:
Multi-Systemic Disease
ASF
What
Family of Asfarviridae family
DNA virus
Slow spread
not much in secretions
MAINLY in tissue and blood
Natural host= Tick
Can infect= domestic pig, wild boar, bush pig, giant forest hog
Transmission
Direct:
infected somestic/ wild pigs
Indirect:
ingestion of contaminated materials
Contaminated fomites
/ biological vectors (soft ticks)
Incubation= 4-19d
CS
Haemorrhage
Acute (4-19d)
Fever, red-purple skin, death
GI signs
vomiting, D+
N
Lack of control
Lameness/ swollen joints
Resp
oculonasal discharges, nose bleeds,
coughing, difficulty
Abortion (Fever)
Deformities
Chronic
Lower mortality rates
Weight loss/ stunting
Intermittent fever
Reduced apetite
Depression
Resp
signs
Chronic skin ulcers
Arthritis
Multifocal redness
PM
Swollen Spleen, congestion, haemorrhages (kidney, LN and Heart), Fluid in thoracic cavity and pericardial sac
Pathogenesis
Replicates in monocytes and macrophages of LN (closest to site of infection)= spreads through blood and lymphatics
Dx
PCR
Serology
Histo
Tx
Hard to kill
(R to temp variations- 70 degrees needed for 30 mins, wide range of pH)
Bleach/ citric acid
NO TX OR VACC AVAILABLE
SQUASHED BY
AN ELEPHANT
CSF
Classic Swine Fever (Hog Cholera)
What
Transmission
Oral fluids
In utero
Incubation
2-6d
Family:
Flaviviridae
Genus:
Pestivirus
Pig Natural host
CS
SAME AS ASF= NEED LAB TEST
Increased mortalities
Fever
Reduced apetite
Skin reddening
Blueness of extremities
CONJUNCTIVITIS
D+
Vomiting
Abortion (fever)
PM
die rapidly- few signs
Haemorrhage
swollen LN
Infarction of spleen
CSF ulceration
Dx
Antigen
AB ELISA
PCR
(fresh tissue, Whole blood-EDTA/ Serum)
Tx
Difficult
(R to low temp, 66 degrees for 60 mins, some disinfectants-
lipid envelope
,
sensitive to UV
)
Vacc
Notifiable
Slaughter
VAMPIRE
smaller than elephant- RNA virus
Assoc. with haemorrhage
Sensitive to UV light
Ddx
Acute PRRS
Porcine Dermatitis and Nephropathy syndrome
Erisipelas
Salmonellosis
pleuropneumonia
PCV2AD
Porcine Circovirus
What
Key Agent in development of a number of disease
Type 2 ONLY
Type 1 and 3= not assoc. with Dx
Pathogen EVERYWHERE on pig farm- need other factors to cause Dx
Forms/ Syndromes
Enteric For
Resp form
Wasting form
Reproductive form
Post-weaning multisystemic wasting syndrome (Exotic)
Porcine dermatitis and nephropathy syndrome (Type 2 hypersensitivity)
CS
PM
Elnarged LN
Gastric Ulcers
Significant coinfections= PPRS, Porcine Parvovirus, Salmonella, Influenza, M. hyponeumonia, L. intracellularis (+/- H. parasuis, S. suis, B. pilosicoli)
"Runs a circle around the pig."
Lymphadenomegaly (immunosuppression- hides from immune system)
When 3-16 wks old
Non specific= weight loss, emaciation, tachypnoea, pallor, jaundice, gastric ulcers, scouring, repro signs, PDND- skin lect.
Dx
CS: Wasting
Hx: depletion of lymphoid tissue
PCV2 infection- Immunohistochemistry (fixed tissue, AB with light on it)
Tx
NONE
Euthanasia
Vacc
progeny
at weaning
(one shot)
Incubation= 4-10d