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Atherosclerosis (Definition (lead to (rupture of (aorta, or other large…

- - - - that may calcify
  - - - aorta
      - or other large arteries
- - - - Sheer stress: tendency to be pulled along or deformed by flowing blood.
      - most marked at point where arteries branch. ( where lipid accumulate to greatest degree)
  - - - Macrophages
      - Natural antibodies
      - innate effector protein
        
        C-reactive protein
        
        complement
    - - Macrophage migration inhibitory factor
      - type 1 interferon
    - - in vicinity of foam cells are stimulated move from media -> intima
        
        where they proliferate
        
        lay down collagen and other matrix molecules.
      - take up oxidized LDL
        
        become foam cells.
        
        lipid accumulate
        
        intracellularly
        
        extracellulary.
  - - - expressed on macrohages
        
        cooperate with toll-like receptors to
        
        stimulate inflammation
        
        drive atherogenesis
    - - uptake oxidized LDLs into macrophages
      - & formation foam cells
    - - 2nd decade
        
        in coronary arteries
      - 3&4th decades
        
        in cerebral arteries
      - 1st decade
        
        in aorta
  - - - T cell
      - monocytes
  - - - plaqus with broken or defective caps
        
        prone to rupture
        
        trigger thrombosis-> block blood flow