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COVID19 strategies (Broad Spectrum (pH-dependent (Chloroquine phosphate…
COVID19 strategies
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Antibodies
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Anti-S protein RBD
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Patient sera more reactive to S-protein than just RBD and sera. Low background and cross-reactivity (High avidity?)
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COVID Seroconversion
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Okba et al. 2020_IgA-based ELISAs were more sensitive, but less specific than IgG ELISAs
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Zhanget al 2020_Viral antibodies can be seen in nearly all patients after day 5 (transition from early to later period). IgM increased from 50 to 81% and IgG from 81 to 100%
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S-protein inhibitor
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S1 varies more between strains (73% conserved) whereas S2 subunit is more conversed (90%) between SARS-CoV strains
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