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Neonatal Jaundice (Hyperbilirubinemia Overview (Accumulation of lipid…
Neonatal Jaundice
Hyperbilirubinemia Overview
High production + immature liver function + biliary recirculation
Incidence: ~50%
Onset: 48-72 hours
Peak: 3-5 days
Accumulation of lipid-soluble unconjugated bilirubin
Unconjugated bilirubin is toxic
Bilirubin encephalopathy: Kernicterus
Treatment
Breastfeeding (but can also contribute)
Colostrum: laxative qualities => eliminates bilirubin
Bowel movements decrease re-circulation of bilirubin
Phototherapy
Bilirubin transformed by blue or blue-green light to photobilirubins
Hydrophilic isomers
Easily excreted
Exchange transfusion
Bilirubin
Product of hemoglobin breakdown
Neonatal RBC lifespan: 70-90 days
Immature liver lacks adequate enzymes to conjugate
Liver-conjugated bilirubin (hydrophilic) excreted via GI and renal