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Parathyroid hormone parathyr (Mechanism of Action (Both required for…
Parathyroid hormone
Mechanism of Action
Both required for normal bone metabolism
N-terminal responsible for the bone building effects
N-terminal and C-terminal regions of the molecule
C-terminal has antiresorptive activity and is necessary
Mediated through binding cell-surface receptors
For normal regulation of N-terminal fragment activity
Side effects
Joint pain
Pain in arms or legs
Headache
Upset stomach or throwing up
Diarrhea
Contraindications
Radiation therapy of the bones
Sensitivity to parathyroid hormone
High levels of alkaline phosphatase
If you are breast-feeding
Paget's disease
Indications
Parathyroidectomy
Hypocalcaemia
Osteoporosis
Route of Administration
Intramuscular administration
Storage conditions
Do not freeze
Protect from heat
Store in original container
Protect from light
Before mixing, store in the refrigerator
