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Ebola (Behavior (Spread (direct contact with contaminated bodily fluids,…
Ebola
Behavior
Spread
direct contact with contaminated bodily fluids
entry points
nose
mouth
eyes
open wounds
cuts/abrasions
initial animal to human
On Cell
attaches to surface receptors:
C-type lectins
DC-SIGN
integrins
In cell
after attachment taken in by cell and...
travel to acidic endosomes and lysosomes where glycoprotein is cleaved
allows virus to release viral nucelocapsid
Replication
RNA polymerase encoded by L gene transcribes genes to mRNAS
Results in full length, positive strand antigenomes
Out of cell
virus invades immune system inhibiting parts of its defense
Target Proteins
C-type lectins
DC-SIGN
Integrins
Treatment
Supportive Care
oxygen therapy
supportive intensive care
IV Fluids
Medications
blood transfusion
No confirmed cure
good options: regeneron and mAB114 (antiviral drugs)
U.S. did develop a vaccine
Structure
shape of shepred's crook, may be coiled
80 nanometers width 14,000 nanometers long
Symptoms
Initial
fever
headaches
muscle pain
chills
Later
internal bleeding
vomiting
coughing blood
organ failure
lead to death
Type of Nucleic Acid
viral RNA
single stranded
Name
Origin
first outbreak was in a village near the Ebola River
Caused by
4 of 5 viruses in the ebolavirus family
Bundibuygyo virus
Sudan virus
Tai Forest Virus
Ebola virus
Target Host Cells
replicates efficiently in many cells
monocytes
macrophages
dendritic cells
liver cells
fibroblasts
adrenal gland cells