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General Anesthesia (Unconscious (Propofol (ADME (Lipophillic, IV…
General Anesthesia
Unconscious
Propofol
Sedative hypnotic
Onset: 15-30 seconds
Increases GABA
Side effects
Respiratory depression
Hypotension
ADME
Lipophillic
IV continuous infusion
t1/2: 3 minutes
Liver metabolism
Renal excretion
Isoflurane
Halothane
Nitrous oxide
Muscle Paralytics
Acetylcholine antagonists at Nicotinic receptor
SNS, PNS, and skeletal muscle junctions
Drugs
Vecuronium
Rocuronium
Muscle relaxant (including diaphragm)
Rapid intubation and mechanical ventilation
Kinetics
Onset: 1-3 mins
Duration: 15-60 mins
Liver metabolism and excretion
Pancuronium
Succinylcholine
Botox
Analgesia
Opioids
Fentanyl
Inhibits Substance P