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ACROMEGALY DUE TO PITUITARY MACROADENOMA (Complications of Acromegaly…

- - - - Known as adenohypophysis
        
        Composed of glandular tissue
      - Supply by Superior and inferior hypophyseal arteries.
        Supply by hypophyseal vein
      - Pars tuberalis, pars intermedia, pars distalis
        
        Lactotroph : Prolactin
        
        Corticotroph : ACTH
        
        Thyrotroph : TSH
        
        Gonadottroph : FSH, LH
        
        Somatotroph : Growth hormone
        
        Physiology
        
        Function
        
        Promote protein synthesis and growth
        
        Lipolysis
        
        Increased blood glucose
        
        Stimulation
        
        Stimulated by GHRH
        Inhibited by GIH/ somatostatin
        
        hyperfunction
        
        PRL
        
        ACTH
        
        LH/FSH
        
        TSH
    - - Known as neurohypophysis
        
        Composed of neural secretory tissue
      - Consist of modified glial cells (pituicytes)
      - Herring bodies
  - - - 1.visual defect (bitemporal hemianopia, diplopia)
      - 2.excessive secretion of hormones
      - 3.less secretion of hormones
      - 4.pituitary apoplexy
      - 5.headache
- - - - Insulin resistance
        
        Hyperinsulinemia
        
        Vascular Resistance
        
        Hypertension
      - Increase skeletal growth
        
        Jaw
        
        Prognathism
        
        Frontal Bone
        
        Frontal Brossing
      - Increase proliferation of cells and synthesis of protein
        
        Overgrowth of tongue
        
        Macroglossia
        
        Overgrowth of skin
        
        Coarse palmar skin
      - GH receptor stimulation in adrenal cortex
        
        Aldosteron Secretion
        
        Sodium and Water Retention
        
        Volume Expansion