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Cannabinoids (Effects (Increased appetite, Decreased pain, Alterations in…
Cannabinoids
Effects
Increased appetite
Decreased pain
Alterations in emotional in emotional and cognitive processes
Loss of focus, memory loss
Increased dopamine overtime
ADME
Smoking
Most rapid absorption
Peak: 3-10 minutes
Oral administration (edibles)
Slowest absorption
Peak 1-2 hours
Lipophilic
high volume of distribution
Liver metabolism
CYP450
Elimination
Feces: > 65%
Urine: 20%
THC Resin
Extracted from marijuana
Highly concentrated THC
Hallucinations
Volatile VS changes
Hallucinations
Kinetics and Dynamics
THC receptors agonize CB1 and CB2
CB1: central and peripheral nervous systems
majority of receptors are in the hippocampus and amygdala
CBD modulates CB1 and CB2
Hashish
Cannabis plant product
THC content varies