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Antifungal Agent (Drugs for systemic fungal infections (Antifungal azoles,…
Antifungal Agent
Drugs for systemic fungal infections
Antifungal azoles
Ketoconazole
Inhibition of human P450 interferes with biosynthesis of adrenal and gonadal steroid hormones
Fluconazole
reatment and secondary prophylaxis of cryptococcal meningitis.
Itraconazole
Treatmentofdermatophytoses and onychomycosis .
The only agent with significant activity against aspergillus species.
Echinocandins
micafungin
anidulafungin
Caspofungin
Pyrimidine antimetabolites
Flucytosine
Non-polyenes
Griseofulvin
Polyene antibiotics
Amphotericin B
Regular Amphotericin B
Produced by Streptomyces nodosus.
binds to ergosterol in fungi
Liposomal Amphotericin B
Lipid formulations distributes mostly in reticular endothelial tissue (liver, spleen, lung), but less in kidney.
Nyatatin
Level of invasion by fungal pathogens
Superficial
Cutaneous
Subcutaneous
Drugs for superficial fungal infections
Systemic drugs
Griseofulvin
Derived from a species of penicillium
Deposited in newly forming skin where it binds to keratin
Iodide
Topical drugs
Haloprogin
Azoles ; Greater affinity for funfal than for human
cytochrome P450 enzymes,Imidazoles exhibit a lesser degree of specificity than the triazoles
econazole
clotrimazole
miconazole
Imidazoles: Ketoconazole, Miconazole, Econazole, Clotrimazole, Bifonazole
Triazoles: Itraconazole, Fluconazol, Vorionazole → systemic treatment
Tolnaftate
MOA unclear butcaninhibitSqualene epoxidase
Nystatin