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Biology Ch 8-9 (Enzymes (Enzyme-substrate complex (When the enzyme binds…
Biology Ch 8-9
Enzymes
A macromolecule that acts as a catalyst, a chemical agent that speeds up the reaction without being consumed by the reaction.
Activation energy
The initial investment of energy for starting a reaction, the energy required to contort the reactant molecules so the bonds can break.
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Enzyme-substrate complex
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A temporary molecule formed when an enzyme comes into perfect contact with its substrate. The substrate causes a conformational change, or shape change, when the substrate enters the active site. The active site is the area of the enzyme capable of forming weak bonds with the substrate.
Active site
It is a region where typically a pocket or groove on the surface of the enzyme where catalysis occurs
Enzymes work by binding to reactant molecules and holding them in such a way that the chemical bond-breaking and bond-forming processes take place more readily.
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Cofactors
Adjuncts that may be bounded tightly to the enzyme as permanent residents, or they may bind loosely and reversibly along with the substrate.
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Competitive inhibitors
Mimics that reduce the productivity of enzymes by blocking substrates from entering active sites. This kind of inhibition can be overcome by increasing the concentration of substrate so that active sites become available.
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Allosteric regulation
Term used to describe any case in which a proteins function at one site is affected by the binding of a regulatory molecule to a separate site.
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Energy
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Free energy
The portion of a systems energy that can perform work when temperature and pressure are uniform throughout the system, as in a living cell.
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Energy coupling
Transfer of energy from catabolism to anabolism, or transfer of energy from exergonic process to endergonic process. (2) Free energy (from ATP hydrolysis) is coupled or functionally linked to the energy needs of another chemical reaction.
Aerobic/Anaerobic
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Occurs in both
Transition Reaction
The transition between glycolysis and the citric acid cycle. The transition reaction converts pyruvate (3 carbons) to acetyl CoA (2 carbons), producing carbon dioxide (CO2) and a NADH
Glycolysis
The process in which one glucose molecule is broken down to form two molecules of pyruvic acid (also called pyruvate). The glycolysis process is a multi-step metabolic pathway that occurs in the cytoplasm of animal cells, plant cells, and the cells of microorganisms.