Please enable JavaScript.
Coggle requires JavaScript to display documents.
7a classification of neurotransmitters (major neurotransmitters of the NS…
7a
classification of neurotransmitters
there are many diff subs known to be NTs
in general,NTs
influence ion channels
-by changing membr potential
fast action
-the ation occurs in ms,so changes induced are
fast & direct
can activate both postsynaptic &
presynaptic receptors
major neurotransmitters of the NS
small molecule NTs
1.biogenic monoamines
acetylcholine A-ch
serotinin ( 5-hydroxytryptamine/ 5HT)
histamine
catechomamines
epinephrine (Ep)
Nor-epinephrine (NE)
dopamine
amino acids
excitatory aa
glutamic acid
Aspartic acid
inhibitory aa
Gamma-aminobutric acid
(GABA)
glycine
large molecule NTs
1.polypeptide NTs
enkephalins & endorphines
substance P
neuropeptide Y
2.purinergic NTs
adinosine
ATP
3.other NTs
nitric oxide (NO)
prostaglandins
for many NTs
-the common steps involeved
in the process of Ntransmission
include;
uptake of a Ntransmitter precursor
into a nerve terminal
biosynthesis of the NT
its storage in synaptic vesicles
its release into the synaptic cleft
-in response to depolarization of
the nerve terminal
binding of the NT to receptors
on the membr of postsynaptic target
& rapid termination
of its action via:
-diffusion away frm the synapse
-reuptake into the nerve terminal
-or enzymatic degradation