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Opioid Analgesics (Endogenous Opioid Peptides (Endorphins- primary peptide…
Opioid Analgesics
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Opioids Classification
Strong agonist:
- Morphine
- Fentanyl
- Meperidine
- Methadone
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- Cross placenta
- Some contraindications
- Meperidine . Obstristics
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Mixed agonist-antagonist:
- Buprenorphine
- Pentazocine
- Nalbuphine
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Antagonist:
- Naloxone
- Naltrexone
- Nalmefene
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- Naloxone --> Short onset 30s IV
- Nalmefene --> Parenteral
- Naltrexone --> Orally = Long duration
Toxicity
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Treatment
- IV Naloxone
- Ventilatory support
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