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Liothyronine lio (Mechanism of Action (Thyroid receptor proteins attached…
Liothyronine
Mechanism of Action
Thyroid receptor proteins attached to DNA
Hormone nuclear receptor complex activates gene transcription
Triiodothyronine (T3) and L-thyroxine (T4) diffuse into the cell nucleus and bind
Synthesis of messenger RNA and cytoplasmic proteins
Physiologic actions through control of DNA transcription and protein synthesis
Contraindications
Adrenal insufficiency
Congestive heart failure
Heart disease, angina (chest pain);
Any type of diabetes
Thyrotoxicosis,
Indications
Myxedema
Thyroid Supression Therapy
Pituitary thyroid-stimulating hormone (TSH) suppressantts
Myxedema Coma
Hypothyroidism
Route of Administration
Intravenous
Oral route
Side effects
Headache
Vomiting
Tremor
Nervousness
Weight loss
Storage conditions
Keep out of the reach of children.
Keep away from direct light
Do not keep outdated medicine
Store at room temperature
Keep from freezing
