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Cancer Support (Cytotoxic chemotherapy (Taxanes (Paclitaxel (Infusion…

- - - - Myelosuppression (esp thrombocytopenia)
      - Dosed by AUC w/ Calvert eqn
    - - peripheral neuropathy
        
        acute(3-5 days, worsens w/ progressive tx)
        
        Delayed neuropathy - cold trigger (swallowing glass)
    - - oto- and nephrotoxicity (esp. cisplatin)
      - peripheral neuropathy
      - emesis
      - anemia
  - - - Infusion reactions
        
        Manage w/ premeds
        
        reduce infusion rate
        
        Switch to nab-paclitaxel
        
        Desensitize patient
      - Peripheral neuropathy
      - Neurotoxicity
    - - Fluid retention
    - - myelosuppression
        
        Neutropenia
        
        RBC depletion -> tired, lack of O2, SOB
        
        Thrombocytopenia
        
        bleed
- - - - acneiform rash
        
        treat with topical corticosteroids/abx (doxycycline/tetra) -> interrupt/halt EGFR -> isotretinoin
      - Diarrhea
      - Myelosuppression (but not as bad as cytotoxics)
      - Nausea
  - - - HTN
      - Bleeding, thrombotic events
      - Delayed wound healing (DNU within 28 days of major surgery)
      - BBW for GI perforation (take abdominal pain seriously)
- - - - PD1 on cytotoxic T cells
      - PD-L1 expressed on cancer cells