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CKD-MBD (Clinical presention (abnormalities of Ca++, PO4, PTH, FGF23, vit…

- - - - Most potent for inducing hypercalcemia
    - - Binds less to GI receptors
    - - Binds less to GI receptors
    - - Bind to suppress PTH production and secretion
        
        work in the intestines to
        inc. abs. of ca++ and PO4
    - - GI upset
      - Hypercalcemia
      - muscle spasms
      - cramps
      - HA
  - - - PTH gland responds to feedback
        
        As [Ca++] ^, [PTH] should go down
    - - mimetics don't raise Ca++ :check:
      - Doesn't interact w/ sevelamer like calcitriol does :red_cross:
    - - HYPOcalcemia
        
        SO look at Ca level to choose HPTH treatment
- - - - Death
  - - - Begins to sacrifice other labs in CKD stage 2+
        
        Secondary HPTH
        
        Begins early in course of CKD, eGFR <60
        
        Occurs d/t these abnormalities (in order to maintain PTH):
        
        PO4 retention
        
        Dec. [Ca++]
        
        Dec. [calcitriol]
        
        Inc. FGF23