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4b Types of synapses ( most common types) (Physiological classification,…
4b
Types of synapses
( most common types)
1.Axo- dendritic synapse
Between axon & dendrite
Main locations:
motor neurons in the spinal cord
excitatory synapse in cerebral cortex
climbing fibers in cerebellum
Axo-somatic synapse
Betw Axon & soma/perikaryon
motor neurons in spinal cord
basket cells of the cerebellum
autonomic ganglia
3.Axo-axonal synapse
Betw Axon & Axon
spinal cord
Dendrone-dendritic synapse
Betw dendrite & dendrite
synapse betw mitral & granule
cell in the olfactory bulb
Anatomical classification
of synapses
Type 1
shows marked thickening of
the synaptic cleft
synaptic cleft
wider
(30nm)
&
filled with dense extracellular
material
Eg: Axodendritic synapse
Type 2
subsynaptic membrane shows
slight
thickening
which is
non-continuous
synaptic cleft is
narrow
(20nm)
&
no such dense materials found here
Eg: Axosomatic synapse
Physiological classification
1.chemical synapses
where impulse in presynaptic cell
causes secretion of
Chemical neurotransmitter
Most synaptic
transmission are chemical
Chemical synaptic transmission
An impulse reaches the
excitatory
synaptic bouton
Results in
release of a
transmitter substance
into the synaptic cleft
Increased permeability of
postsynaptic membrane to
Na+ & K+
results in
Greater Na+ influx
than K+ efflux
due to greater
electrochemical gradient
for Na+
The resultant current flow
is in a direction
that tends to depolarize the
postsynaptic cell
if threshold is reached- an action potential
occurs in the postsynaptic cell
An impulse reaching the
inhibitory
synaptic bouton
results in
the release of a
transmitter substance
into the synaptic cleft
Incr permeability of
postsynaptic membrane to
Cl-
results in
Cl- influx
The resultant current flow is in a direction
that tends to
hyperpolarize
the postsynaptic cell
as a result
greater depolarization
of the postsynaptic cell
is required to reach
threshold
Electrical synapse
Where Transmission is
electrical
Conjoint synapse
Where transmission
is both
chemical & electrical