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RMP in cell migration and wound healing (Initiate cell migration to…
RMP in cell migration and
wound healing
Initiate cell migration to wounded area
Effect more apparent in more
depolarised membrane potential
Osteoblast (RMP below -40mV)
Chondrocytes in callus formation (RMP below -40mV)
Cell with RMP below -30mV: undifferentiated cells & mesenchymal stem cells
Tyoe of cell migration
Individually (lose cell-to-cell junction)
As cohesive sheet
Allow excitable cells to experience rapid electrical changes
Cells perfom its proper role for wound healing
Ignore other physiological signals
Allow ENaC (epithelial sodium channel) to function
Reference
Brunet, T., & Arendt, D. (2016). From Damage Response to Action Potentials: Early Evolution of Neural and Contractile Modules in Stem Eukaryotes. Philosophical Transactions Of The Royal Society B: Biological Sciences, 371(1685), 20150043. doi: 10.1098/rstb.2015.0043
Chrysafides, S., & Sharma, S. (2020). Physiology, Resting Potential. Retrieved 15 March 2020, from
https://www.ncbi.nlm.nih.gov/books/NBK538338/
Abdul Kadir, L., Stacey, M., & Barrett-Jolley, R. (2018). Emerging Roles of the Membrane Potential: Action Beyond the Action Potential. Frontiers In Physiology, 9. doi: 10.3389/fphys.2018.01661
Zhao, M. (2009). Electrical Fields in Wound Healing—An Overriding Signal that Directs Cell Migration. Seminars In Cell & Developmental Biology, 20(6), 674-682. doi: 10.1016/j.semcdb.2008.12.009
Brian Reid and Min Zhao (2014)The Electrical Response to Injury: Molecular Mechanisms and Wound Healing.doi: 10.1089/wound.2013.0442 ,from
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928722/
Wound
Generate electrical field/ force
EF migrate to neighboring cell
Resulting the cells to override other physiological cues/signals
Initiates directional cell migration towards the wounded area
Reorganisation of actin cytoskeleteon
Cell proliferates and differentiates
Wound healing occur
sodiuam ion channel enhanced the membrane depolarization at edge of wounds,
extend the depolarization to neighbouring cell,
depolarization will support the development of actin reorganization
epithelial cells migrate directionally to the negative pole (cathode), which at a wound is the field polarity
pointing (positive to negative) to the wound center.
CLICK FOR CLEARER DIAGRAM :arrow_down:
https://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=3928722_fig-1.jpg
Cues are internal or external events which have a signalling significance to an organism
a significant EF is generated by the directional flow of charged ion species or ion flux due to leakage from damaged cells
ion flux can also be due to leakage from damaged cells
The ends of the cell that face the two poles of the field will experience the largest EF
healing after injury has been described by two major mechanisms, cell migration and cytoskeleton reorganization
WHAT HAPPEN DURING WOUND HEALING ?
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