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lesion studies (statistical analysis (voxel-based morphometry (estimation…
lesion studies
statistical analysis
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voxel-based morphometry
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suitable for measuring subtle differences, but not for more profound damage, e.g. stroke , since damaged tissue cannot be identified by routines
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aligning brain images in common stereotaxic space to allow comparison between patients and healthy individuals
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limitations
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differential vulnerability - some areas are more likely to be affected by damage, e.g. stroke, therefore damage might not be randomly distributed in the brain
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control groups
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healthy control (single dissociation), control group with different damage (double dissociation)
dissociation
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does not allow to infer that function A is localised in structure A, but that structure A is necessary for function A
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example:neglect
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extinction
simultaneous presence of two stimul (right and left hemifield) lead to extinction from awareness of one stimulus
however, when presented separately, both stimuli can be detected (kn right and left hemifield)
thus, neglect does not result from primary visual deficit
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