Acts on aldosterone antagonist which blocks the aldosterone in the distal tubule

Hyperaldosteronism, used as adjuncts with thiazide or loop diuretics in patients who are especially at risk of hypotension

Causes the loss of sodium while the retention of potassium.

Intravenous fluid replace to maintain sodium and potassium levels

Inhibits epithelial sodium channels on the distal convoluted tubule and the collecting ducts which are transmembrane channels that normally promote sodium uptake and potassium secretion

Exerts diuretic effect of the distal tubules to inhibit reabsorption of sodium ions in exchange for potassium